Embedded Files
Small Multidrug Resistance transporters efflux toxic compounds
Export of toxic compounds by efflux pumps is a primary mechanism of antibiotic resistance.
The Small Multidrug Resistance (SMR) transporters are the smallest-in-size family of efflux pumps and are expressed by several high priority pathogens, including Pseudomonas aeruginosa.
SMRs provide a minimal model to understand transport, due to their small size and limited potential binding sites.
Alphafold Model of PAsmr, an SMR from P. aeruginosa
At the 2023 Mechanisms of Membrane Transport GRC, Les Diablerets, Switzerland
In my doctoral work with Dr. Katie Henzler-Wildman, I showed that PAsmr, a small multidrug resistance transporter from Pseudomonas aeruginsa, may confer either resistance (due to antiport behavior) or susceptibility (via proton uniport) depending on the substrate.
I also carried out a screen of several other SMRs and over 200 antimicrobial compounds to identify novel substrates and determine if they were also capable of opposing biological outcomes in a substrate-dependent manner.
Page updated
Google Sites
Report abuse